Researchers at Israel’s Weizmann Institute have analyzed the build-up of ammonia that impairs immune cells in 50% of cancer patients. It blocks the protein regulator HNF4-alpha, causing weight loss and tumor growth. In lab tests, restoring HNF4-alpha production stops weight loss and shrinks the tumors.

https://www.israel21c.org/why-cancer-patients-suffer-weight-loss-and-how-to-stop-it/

https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-22-1062/718964/Early-infiltration-of-innate-immune-cells-to-the