Tel Aviv University researchers have confirmed the effectiveness of bipolar depression sufferers combining mood stabilizers with anti-depressants. 81.7% of patients using both avoided re-hospitalization (for manic episodes), compared to only 57.6% of patients who did not receive the combination.

https://www.israel21c.org/study-identifies-new-method-of-treating-bipolar-depression/

https://www.europeanneuropsychopharmacology.com/article/S0924-977X(18)30030-0/abstract