For decades, scientists believed that paracetamol relieved discomfort by working only in the brain and spinal cord. Now, Hebrew University of Jerusalem scientists show that the AM404 active metabolite which it releases, shuts off sodium channels to stop pain signals while they are still at nerve endings.

https://www.timesofisrael.com/israeli-study-finds-acetaminophen-drug-works-by-first-blocking-pain-in-nerves/

https://www.pnas.org/doi/10.1073/pnas.2413811122