Scientists at Israel’s Ben Gurion University have found saccharin, aspartame, and sucralose disrupt the mechanism that gut bacteria use to keep us well. Acesulfame potassium (Ace-K), advantame, and neotame did not have this effect. The results have relevance for obesity and diabetes.

https://www.timesofisrael.com/sweeteners-hurt-the-ability-of-gut-bacteria-to-keep-us-well-israeli-study/

https://in.bgu.ac.il/en/pages/news/artificial_sweeteners_disruption.aspx

https://www.mdpi.com/1422-0067/22/18/9863