Scientists at Israel’s Weizmann Institute and in Germany, have clarified the molecular cascade triggered by ketamine, that leads to its sustained antidepressant effects. They found that the gene Kcnq2 enables potassium ions to pass through the brain, maintaining the activity and stability of neurons.

https://www.timesofisrael.com/israeli-german-study-hopes-to-pave-way-for-use-of-ketamine-as-an-antidepressant/