Doctors at Israel’s Sheba Medical Center made history with a 7-hour operation to deliver Upstaza gene therapy directly to the brain of a 4-year-old girl from India. The NIS  10 million cost per vial was the most expensive single Israeli surgery ever and was given free of charge.

https://www.israelhayom.com/2023/04/02/israeli-doctors-make-history-with-gene-therapy-treatment-to-brain/