Researchers at Israel’s Weizmann Institute have found a gene in the non-coding (“junk”) part of the genome that reduces five-fold the risk of developing amyotrophic lateral sclerosis (ALS). The gene IL18RAP can contain mutations that reduce inflammation in the brain.

https://weizmann-usa.org/news-media/news-releases/mutations-in-noncoding-dna-protect-the-brain-from-als/

https://www.timesofisrael.com/identifying-als-preventing-mutation-israeli-researchers-hope-for-path-to-treatment/