Tel Aviv University scientists have identified pathological activity in the brain that precedes initial Alzheimer’s symptoms by many years. A systemic failure causes high activity in the hippocampus even during sleep. They also found that an existing MS treatment suppresses this activity.
https://www.jpost.com/health-and-wellness/article-695244
https://www.sciencedirect.com/science/article/pii/S2211124721017800